Pet Factsheets

Client Factsheets > Dogs > Medication: Grapiprant

< Back to search

CONTRIBUTOR(S): Vetstream Ltd, Gigi Davidson, Fear Free,

Medication: Grapiprant

Medication: Grapiprant

Your dog has been prescribed the active ingredient grapiprant for the control of pain and inflammation associated with osteoarthritis.

Key points:
•Anti-inflammatory.
• For dogs over 9 months of age and weighing more than 3.6 kg (8lbs).
• Dosage: once daily.
Do not give at the same time as other anti-inflammatory drugs (eg NSAIDs, aspirin, corticosteroids).
• Do not give pregnant, lactating or breeding dogs.
• Use with caution in dogs with liver, heart, kidney or gastrointestinal tract disease.
• Grapiprant is a sulfonamide drug. Caregivers with sulfa allergies should use caution when handling.
• Dogs that are known to have the ABCB1-Δ genetic polymorphism (the MDR1 Mutation) may require a lower dose of this drug to avoid adverse effects.

This information sheet is designed to help answer commonly asked questions and help you give the medication safely and effectively to your pet. It does not contain all available information for this medication. If you have other questions or need more information, contact your veterinarian or pharmacist. Always follow the dosing instructions provided by your veterinarian. 

Name, Brand names, Class of medication and Storage

Name
  • Grapiprant (GRA-pi-prant).
Brand name
  • Galliprant®.
Class of medication
  • Prostaglandin E2 EP4 receptor antagonist (piprant).
  • Non-cycloxygenase inhibiting, non-steroidal anti-inflammatory drug (NSAID).
Storage
  • Store at or below 86° F (30° C).

Why has my dog been prescribed grapiprant?

Your veterinarian has prescribed grapiprant for the control of pain and inflammation associated with osteoarthritis. Although it is an anti-inflammatory drug, grapiprant does not reduce fever.

How is the medication given?

Grapiprant is given orally as a flavored chewable tablet. It is given once daily on an empty stomach at least one hour before the next meal. If your dog vomits, try giving the next dose with a little food to see if this helps.

Are there any side-effects or drug interactions?

Side-effects may include:

  • Vomiting  – generally mild and short-lived
  • Diarrhea
  • Decreased appetite
  • Mucoid, watery or bloody stools
  • Decreases in serum albumin and total protein.
  • Adverse effects may be increased in dogs that are known to have the ABCB1-Δ (MDR1) genetic polymorphism.

Call your veterinarian if any of the above side effects persist.

Let your veterinarian know if your dog is taking any other medications, vitamins, or supplements. Ask your veterinarian before giving any of the drugs below:

  • Other anti-inflammatory drugs (eg NSAIDs – carprofen, meloxicam, firocoxib, aspirin, etc).
  • Corticosteroids (eg prednisone).
  • Diuretics (eg furosemide).

How long will my dog need to receive this medication?

As osteoarthritis is a chronic condition, your dog may need to be given grapiprant on a long-term basis. If the medication is stopped, your dog’s symptoms will return.

How should I dispose of this medication if I don’t use it all?

Dispose of any unused grapiprant safely – don’t flush away down the toilet or sink. Ask your veterinary team if they take back medication for disposal. Do not save grapiprant for future use or give to other pets.

What if I miss a dose or give an extra dose?

If you miss a dose, give the dose as soon as possible but do not double up a dose. Make sure the dose given doesn’t exceed the total recommended amount in any 24-hour period.

My dog is unwell, should I still give the drug?

If your pet is unwell, contact your veterinarian for advice.

What should I do if this medication is accidentally given to another pet or taken by a human?

Grapiprant should only be given to the dog that it has been prescribed for:

  • Do not give to other pets in the household
  • Do not use in dogs under 9 months of age and weighing less than 3.6 kg (8 lbs)
  • Do not use in dogs with cardiac disease
  • May cause adverse effects in dogs with kidney, liver, or gastrointestinal disease
  • If accidentally given to other pets, contact your veterinarian for advice.

If accidentally eaten by a human, speak to your primary care physician or poison control center as grapiprant is not approved for use in humans.

Will my dog need to be monitored while on grapiprant?

If used long-term, regular monitoring is recommended.

Further information

If you have any concerns, further information on grapiprant can be found on the package insert and the following websites:

Europe & UK

USA

Always follow the recommended dosage and contact your veterinary team or pharmacist if you have any questions regarding your dog’s medication.

Scroll to top